Here you will find a selection of studies which are currently recruiting people with Long Covid.
If you are a research scientist and wish to have your study featured here, please contact us at
Take Part in Research
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PHOSP-I Study (UK)
Full Trial Title: A phase 2a double blind, randomised placebo-controlled trial of Tocilizumab to investigate the effect on health-related quality of life in adults with Long COVID and persistent inflammation (PHOSP-I).
Outline: This trial aims to investigate whether a medication called Tocilizumab will improve symptoms and help improve health-related quality of life in people living with Long COVID. Tocilizumab may be effective in treating patients with Long COVID by reducing inflammation and thereby improving symptoms such as fatigue, breathlessness, brain fog and pain. This trial is comparing Tocilizumab with a placebo (‘dummy drug’).
Approximately 150 people will be asked to take part in this trial - including those who were not hospitalised for their acute Covid infection.
There are several sites at which people can participate:
- University Hospitals of Leicester NHS Trust
- Guy's and St Thomas' NHS Foundation Trust
- King's College Hospital NHS Foundation Trust
- University College London Hospitals NHS Foundation Trust
- Oxford University Hospitals NHS Foundation Trust - Recruitment now closed
- Sheffield Teaching Hospitals NHS Foundation Trust
- Cambridge University Trust, Addenbrookes - Recruitment now closed
- University Hospitals of Birmingham NHS Foundation Trust
- NHS Greater Glasgow and Clyde
- Manchester University Hospitals NHS Foundation Trust
- Northern Care Alliance NHS Foundation Trust
- North Bristol NHS Foundation Trust
- University Hospitals of Coventry and Warwickshire NHS Trust
- Cardiff and Vale University Health Board
Study Website: https://www.phosp.org/phosp-i/
Contact study team (please include in your email where you are located):
Neuroimaging and immune phenotyping of long COVID in children (London, UK)
Study aim: This study aims to recruit 80 children and young people with long COVID, and healthy controls. They will undergo in depth MRI imaging, clinical assessment and blood tests looking at immune function, to better understand the mechanism causing damage in long COVID. Their results will be compared with data from 20 children fully recovered from COVID-19 and a large group of healthy controls recruited pre-pandemic. The focus of this research is on the neurological immune response that may occur following significant inflammation within the body.
Where: St Thomas's Hospital, London, England
What will happen: Participants will attend St Thomas hospital to have an MRI scan and give a blood sample.
Who: People from the age of 10 up to 17. Those with Long Covid should have been assessed in the London Long Covid clinics, but healthy control participants can self-refer.
Funders/Sponsors: The study is sponsored by King's College London and funded by Action Medical Research
Contact details: If you are interested in taking part, please email and you will be sent more information
More information: For more information about this study, see the entry on the NIHR Be Part of Research Website https://bepartofresearch.nihr.ac.uk/trial-details/trial-detail?trialId=51487&location=&distance=
PHARM-LC (UK - online)
Study aim: To explore the role of community pharmacy in the UK in supporting the management of people with Long Covid.
Objectives:
- To explore with illness experiences or people with Long Covid, self-management strategies, and past/current/future help-seeking from and community pharmacy teams.
- To explore attitudes and beliefs among community pharmacy staff (pharmacists, technician, dispensers and counter assistants) about their past/current/future role in supporting people with Long Covid.
- To co-design an online training resource to enhance community pharmacy-led support for people with Long Covid.
Where: Online in the UK
What will happen: Participants will have an online interview with a researcher.
Who:
1. People with Long Covid who are over the age of 18.
2. Pharmacy workers (pharmacists, technicians, dispensers and counter assistants) in community pharmacy practices in the UK.
Funders/Sponsors: The study is sponsored by Keele University and funded by the National Institute for Health and Care Research.
Contact details: Please contact Tamsin Fisher on
More information: If you are interested in participating and would like more information please see the PHARM-LC website https://www.keele.ac.uk/health/fmhsresearchthemes/mentalhealthandwellbeing/pharm-lc/
Long Covid and the Carotid Chemoreflex (Bristol, UK)
Why is the study being conducted: Some people with long-COVID experience exercise intolerance, and breathlessness at rest, and during exercise and fatigue. We know that the carotid bodies may play an important role in these symptoms, as we have shown previously that the carotid bodies are overactive in people with long-COVID.
Study aims: The aims of this study are to investigate whether ‘switching off’ the carotid bodies can improve breathing efficiency during exercise, and reduce hyperventilation at rest, in people with long-COVID.
Where: The NIHR Clinical Research Facility, Bristol, England (https://www.bristolcrf.nihr.ac.uk/getting-here/)
What will happen: Participants will attend the Clinical Research Facility for three visits on separate days. Visit 1 is a screening visit and will involve several questionnaires, a blood pressure and ECG check, a blood sample and lung function and diffusion tests. Visits 2 and 3 will be the same, but a different infusion (dopamine or saline) will be used. We will measure your breathing at rest and during an exercise test on an upright cycle ergometer. If participants need a break during the study visits, or would like a quiet place to rest between, or after the procedures, we can facilitate this within the Clinical Research Facility.
Who: People aged between 18-75 years old who have been diagnosed with long-COVID, and healthy control participants.
Funders/Sponsors: The study is sponsored by the University of Bristol and funded by the Medical Research Council, UK Research and Innovation (MRC, UKRI).
Contact details: If you are interested in taking part, please email and you will be sent more information.
More information: For more information about this study, please visit the study website: Long-COVID and the carotid chemoreflex, or see the entry on the NIHR Be Part of Research website: LINK. Please find a link to our paper published in Nature Communications Medicine: https://pmc.ncbi.nlm.nih.gov/articles/PMC10876702/#CR20
